It's hard to say what the problem is, so I'll ask for some more details.
First of all are you using all of the components required for the new patches? You mentioned the special tomb4.exe, but you also need to have
patches.bin and
flep.dll. Both of these components must be in the main TRLE folder alongside tomb4.exe.
Secondly, which patches are you applying?
Also, giving the contents of the crash log could give a clue for finding the issue. It's not always helpful, but it's worth a shot.